Department of Pesticide Regulation Logo

Paul E. Helliker Director

Department of Pesticide Regulation


   
   
   
   
  California Notice 2000-8
  POST UNTIL September 1, 2000

California State Seal
Gray Davis
Governor

Winston H. Hickox
Secretary, California
Environmental
Protection Agency

NOTICE OF FINAL DECISION CONCERNING
REEVALUATION OF PESTICIDE PRODUCTS


The Director of the Department of Pesticide Regulation (DPR) files this notice with the Secretary of the Resources Agency for posting pursuant to Title 3, California Code of Regulations (CCR), Articles 8 and 12. CCR requires the Secretary of the Resources Agency and DPR to post this notice for 30 days for public inspection.

REEVALUATION

DPR commenced reevaluation of the following pesticide products on November 25, 1997. The pesticide products are rodenticides that contain one percent or more of the active ingredient diphacinone.

REGISTRANT BRAND NAME
U.S. EPA REG. NO.
Bell Laboratories, Inc. 1% Diphacinone Concentrate
12455-71-AA
Haco, Inc. Diphacin 110-A Concentrate
2393-493-AA

BASIS OF REEVALUATION

DPR registers products containing the active ingredient diphacinone for use in and around homes, agricultural, and industrial buildings, and in sewers to control Norway rats, roof rats, and house mice. DPR currently registers 50 products containing diphacinone. Of the currently registered products, 48 are intended for end use and contain 0.2 percent or less diphacinone. Containing one percent and two percent diphacinone, the two remaining products are concentrates intended for use in the formulation of end-use rodenticides.

DPR initiated the reevaluation based on its review of acute toxicity data submitted to support the registration of the one-percent diphacinone product. DPR found the submitted acute dermal toxicity and primary dermal irritation studies to be unacceptable. Without acceptable acute toxicity studies, DPR was unable to determine whether the precautionary statement currently on the label of the product adequately identified acute toxicity hazards. After a search of the database, DPR additionally determined that no acute toxicity studies were on file to support the registration of the two-percent diphacinone product. Adequate acute toxicity data are on file to support the registrations of diphacinone products containing less than one-percent diphacinone.

SUMMARY OF REEVALUATION

In the fall of 1998, the two registrants submitted several acute toxicity studies. DPR reviewed the data submitted to support the one-percent diphacinone product and determined that the acute dermal toxicity study was unacceptable. In July 1999, the registrant submitted a new acute dermal toxicity study. Based on the data, DPR determined that the one-percent diphacinone product was Toxicity Category II for acute oral toxicity, Toxicity Category III for acute dermal toxicity, and Toxicity Category IV for eye and dermal irritation.

After reviewing the data submitted to support the two-percent diphacinone product, DPR determined that an acceptable rabbit acute dermal toxicity study and a dermal irritation study were still needed. In August 1999, the registrant submitted two new studies. Based on the data, DPR determined that the two-percent diphacinone product was Toxicity Category II for acute oral toxicity and acute dermal toxicity; and Toxicity Category IV for eye and dermal irritation.

FINAL REEVALUATION DECISION

The labels of both diphacinone products now adequately identify all acute toxicity hazards. Therefore, DPR concludes this reevaluation.

For further information, please contact Ms. Ann Prichard, Senior Environmental Research Scientist, Pesticide Registration Branch, by e-mail at <aprichard@cdpr.ca.gov> or by telephone at (916) 324-3931.


original signed by Barry Cortez


July 17, 2000


Barry Cortez, Chief
Pesticide Registration Branch
(916) 445-4377

Date

830 K Street - Sacramento, California 95814-3510 - www.cdpr.ca.gov
A Department of the California Environmental Protection Agency