Department of Pesticide Regulation Logo

Paul E. Helliker Director

Department of Pesticide Regulation


   
   
   
  California Notice 2001-7
  November 15, 2001

California State Seal
Gray Davis
Governor

Winston H. Hickox
Secretary, California
Environmental
Protection Agency

NOTICE OF FINAL DECISION CONCERNING
REEVALUATION OF PESTICIDE PRODUCTS


The Director of the Department of Pesticide Regulation (DPR) files this notice with the Secretary of the Resources Agency for posting pursuant to Title 3, California Code of Regulations (CCR), Articles 8 and 12. CCR requires the Secretary of the Resources Agency and DPR to post this notice for 30 days for public inspection.

REEVALUATION

DPR commenced reevaluation of pesticide products containing the active ingredient propetamphos on March 22, 1990.


REGISTRANT BRAND NAME
U.S. EPA REG. NO.
Wellmark International Zoecon Catalyst Emulsified
in Water Insecticide
2724-450-ZA

BASIS OF REEVALUATION

Applicators use propetamphos indoors as an insecticide. DPR initiated the reevaluation based upon illnesses attributed to the use of products containing propetamphos. In addition to the reports of illnesses, DPR was also concerned about the potential for overexposure of humans in rooms treated with propetamphos.

SUMMARY OF REEVALUATION

Pursuant to the reevaluation, DPR required the registrant to submit (1) a dermal sensitization study, (2) an odor threshold study, (3) an indoor exposure study, and (4) a dermal absorption study. The registrant submitted the dermal sensitization study in January 1991. Rather than conduct an odor threshold study, the registrant conducted a sensory irritation study. The registrant submitted the results of the sensory irritation study in June 1993. The results of an indoor exposure study were submitted in April 1994. Rather than conduct a dermal absorption study, the registrant requested DPR use an assumption of 100 percent dermal absorption.

In February 1998, DPR initiated a risk assessment of pesticide products containing the active ingredient propetamphos. In July 1998, DPR issued a notice identifying the definitive toxicity and exposure studies, critical endpoints/no effect levels used in the propetamphos risk assessment.

In November 1999, DPR completed its risk assessment of propetamphos. At the completion of the risk assessment, only one product containing propetamphos remained registered for use in California. Using current toxicity and exposure data, DPR determined that the calculated margins of safety for propetamphos were less than values conventionally considered to be protective of human health. In a notice dated December 27, 1999, DPR informed the registrant that it must institute mitigation measures to reduce exposure from: (1) broadcast applications, (2) gallery (termite) applications, and (3) spot and crack-and-crevice applications made by structural operators. The registrant agreed to amend their product label to: (1) remove all residential, termiticide, spot, and broadcast applications; (2) reduced the maximum rate of dilution from 1.0% active ingredient to 0.5% active ingredient; (3) added personal protective equipment requirements for applicators of crack and crevice applications; and (4) restrict use of the product to licensed Pest Control Operators. DPR accepted the amended label on July 27, 2001.

FINAL REEVALUATION DECISION

The label of Zoecon Catalyst Emulsified in Water Insecticide, EPA Reg. No. 2724-450-ZA adequately mitigates the human health hazards identified in DPR's risk assessment of propetamphos. Therefore, DPR concludes this reevaluation.

For further information, please contact Ms. Ann Prichard, Senior Environmental Research Scientist, Pesticide Registration Branch, by e-mail at <aprichard@cdpr.ca.gov> or by telephone at (916) 324-3931.


original signed by Barry Cortez


October 2, 2001


Barry Cortez, Chief
Pesticide Registration Branch
(916) 445-4377

Date

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