NOTICE OF FINAL DECISION CONCERNING
REEVALUATION OF PESTICIDE PRODUCTS
The Director of the Department of Pesticide Regulation (DPR) files this notice
with the Secretary of the Resources Agency for posting pursuant to Title 3,
Articles 8 and 12 of the California Code of Regulations (CCR). The CCR requires the Secretary of the Resources
Agency and DPR to post this notice for 30 days for public inspection.
DPR commenced reevaluation of four pesticide products containing maneb on
August 11, 1997. DPR registers fungicides containing maneb to control diseases of fruits, vegetables, and field
BASIS OF REEVALUATION
DPR initiated the reevaluation based on data which indicate that products containing maneb have the potential to
be human skin sensitizers. The maneb products placed into reevaluation did not bear a label warning informing users
of the potential skin sensitization hazard.
Skin sensitization (allergic contact dermatitis) is an immunological reaction of skin to a substance. In humans,
such reactions include severe itching, redness, swelling, inflamed spots, blisters, or a combination of these symptoms.
In the assessment and evaluation of the toxic characteristics of a pesticide product, determination of the products
potential to cause sensitization identifies potential hazards to humans repeatedly exposed to the pesticide.
SUMMARY OF REEVALUATION
DPR required registrants to indicate how they intended to mitigate the potential
skin sensitization hazard. One registrant chose to amend the labels of two of its products to add a skin sensitization
warning statement. The registrant withdrew
the California registration of a third product. The second registrant also chose
to amend the label of its product to add a dermal sensitization warning statement.
All amendments to pesticide product labels must be approved by the
U.S. Environmental Protection Agency before they can be accepted by DPR. Both U.S. EPA and DPR accepted the three
FINAL REGULATORY DECISION
The labels of all pesticide products containing maneb now bear a dermal sensitization warning statement. Therefore,
DPR concludes this reevaluation.
For further information, please contact Ms. Ann Prichard, Senior Environmental Research Scientist, Pesticide Registration
Branch, Department of Pesticide Regulation, 830 K Street, 9th-LL, Sacramento, California 95814-3510 or by telephoning