Re-evaluation of Developmental and Reproductive Toxicity of OrthoPhenylphenol (OPP) and Sodium Ortho-Phenylphenate (SOPP)
Abstract
Background: Due to widespread usage, the general public including pregnant women is routinely exposed to the
fungicides, Ortho-Phenylphenol (OPP) and Sodium Ortho-Phenylphenate (SOPP), from many sources. Previous data
reviews concluded no effects on development or reproduction in animal studies but upon re-analysis we realize that
alternative interpretation may exist.
Methods: Developmental and reproductive effects were assessed from studies performed in rats, mice, and
rabbits. We identified the most sensitive endpoint(s) for OPP or SOPP as they related to fetal developmental or
reproductive toxicity. For quantifying the potential health risk associated with the exposure to OPP or SOPP, we used
the lowest dose that caused no developmental or reproductive toxicity or benchmark dose analysis.
Results: Developmental effects in OPP-treated rats and mice were decreased fetal body weight, increased
incidences in delayed skeletal ossification and post‑implantation loss. In addition, fetal mice exposed to SOPP
exhibited malformation. Similar to rats and mice, post-implantation loss was the developmental effect noted in OPPtreated rabbits. Except for the rats, maternal toxicity appeared to be minimal (mice) or not observed (rabbits) at the
lowest dose where developmental effects occurred (mice: cleft plate; rabbits: resorptions). We did not find evidence
of OPP affecting reproductive functions but significant deviations from FIFRA Guidelines in these studies may prevent
adequate assessment of the reproductive toxicity especially the effects on fertility and mating.
Conclusions: The revised data analysis suggests that OPP and SOPP induce fetal toxicity in the absence of
maternal effects. Our re-evaluation would be useful in the formulation of a current or updated regulatory strategy for
the developmental toxicity of OPP and SOPP.