Active Ingredient: Fipronil
Human Health Risk Assessment and Mitigation
Documents and Activities

Risk Characterization Documents (RCDs) estimate the nature and likelihood of adverse health effects in humans who may be exposed to pesticides.

• March 2023 – Final Risk Characterization Document (PDF)
  • January 2023 – Response to Comments by the U.S. Environmental Protection Agency (PDF)
  • January 2023 – Response to Comments by the Office of Environmental Health Hazard Assessment (PDF)
  • January 2023 – Response to Comments by the Fipronil Task Force (PDF)
• December 2022 – Final Exposure Assessment Document (PDF)
  • December 2022 – Response to Comments by the U.S. Environmental Protection Agency (PDF)
  • December 2022 – Response to Comments by the Office of Environmental Health Hazard Assessment (PDF)
  • December 2022 – Response to Comments by the Fipronil Task Force (PDF)
• January 2021 - Draft Risk Characterization Document

Other Documents

• February 2017 – Problem Formulation Document (PDF)
• August 2016 – Problem Formulation Summary (PDF)
• December 1999 – Significance of Dermal Dose Levels in Dermal Absorption Studies of Pesticides (PDF)
• May 1999 – Dermal Absorption of Cyromazine, Diclofop-Methyl, Fenpropathrin, Fipronil, and MB 46513 in Rats (PDF)
• March 1999 – Dermal Absorption of 14C-Fipronil Regent 80 WDG in Male Rats (HWI 6224-210) (PDF)
• March 1999 – Dermal Absorption of 14C-MB 46513 in Male Rats (CHW 6224-230) (PDF)

Enforcement Letters

• August 2005 – ENF 2005-021 - Labeling Interpretation - Termidor® Sc Termiticide/Insecticide

• May 2023 – Completion of Risk Characterization Document (PDF)
• March 2021 – Pesticide Registration and Evaluation Committee Meeting Agenda (PDF)
  • Pesticide Registration and Evaluation Committee Meeting Minutes (PDF)
  • Presentation on Fipronil Draft Risk Characterization Document
• August 2016 – Pesticide Registration and Evaluation Committee Meeting Agenda (PDF)
  • Pesticide Registration and Evaluation Committee Meeting Minutes (PDF)
  • Presentation on the Risk Assessment on Fipronil; DPR's New Process (PDF)
  • Problem Formulation Summary of the Fipronil Risk Assessment (PDF)
• April 2016 – Initiation of the Human Health Risk Assessment (PDF)
• 2015 – Imidacloprid and Fipronil Insecticides, Comparison of In Vivo Toxicity Endpoints and ToxCast Profiles (PDF)
• 2015 – Comparative Toxicity of Endosulfan and Fipronil Insecticides: Utilizing In Vivo and In Vitro Data
• November 2001 – Initiation of Risk Assessment

• Pesticide Product Database
• Human Health Assessment Branch Memos
• Human Health Assessment Branch Publications, Posters/Abstracts and Presentations
• Worker Health and Safety Reports and Memos
• Environmental Monitoring Branch Publications
  • Environmental Fate Reviews
• Air Monitoring Network
• Pesticide Use Reporting (PUR)
• California Pesticide Illness Query (CalPIQ)
• Environmental Justice (EJ)
• OEHHA Proposition 65 Information
• U.S. EPA Pesticide Chemical Search
• PubChem-Chemical Information